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butabarbital will lessen the level or result of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Result of coadministering a solid CYP3A4 inducer with fedratinib has not been analyzed.butabarbital will reduce the extent or impact of aprepitant by impacting hepatic/intestinal enzyme CYP3A4 me

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